It happened on Highway 96, just east of Fremont.
According to the Waupaca County Sheriff's Department, 82-year-old Wayne Tesch as a result of smoke inhalation.
The victim's wife made it out of the home and was transported to the hospital to be treated for smoke inhalation.
The Sheriff's Department says that Highway 96 was at Bellin Road as crews battled the fire.
The cause of the fire is still under investigation, but officials say it's believed to be accidental and not suspicious.
The Red Cross is also assisting the family.