Officers were called to the 1200 block of Driftwood Drive.
The homeowner ways an unknown number of masked people entered through a door and confronted him, leading to a physical altercation.
The homeowner was able to fight off the intruders, who ran away.
Investigators believe this was a targeted and planned break-in.
They remind all residents to lock their homes.
If you have any information that could help call the De Pere police department at (920)339-4078.