ST. LOUIS, Mo. (Ivanhoe Newswire) -- Famous actress Angelina Jolie made headlines when she announced she was having a preventive mastectomy after testing positive for a BRCA mutation. It was a story that caught the attention of women everywhere, but women aren't the only ones who are affected by these genes.
A year ago, Josh Newby quit his successful job at a dot-com company to care for his mom Theresa.
"It's the greatest decision I ever made," Josh told Ivanhoe.
Theresa had stage IV breast cancer and was in hospice until she passed away.
When she was diagnosed, she tested positive for a BRCA gene mutation. She wanted Josh to get the blood test too. His result was also positive.
"I thought, wow, I have this gene. I got to take my life a little more seriously," Josh said.
Genetic counselor Khateriaa Pyrtel says many don't realize men can pass the faulty gene to their daughters and women can pass it on to their sons.
"I do find that it's often like they're not even thinking about the men in the families. We get the same information from our mothers that we do from our fathers in terms of our genes," Khateriaa Pyrtel, MS, CGC, Certified Genetic Counselor, Washington University School of Medicine, told Ivanhoe.
Men and women with a BRCA mutation have a 50 percent chance of passing it on. Women with the mutation are up to seven times more likely to develop breast cancer, and at least ten times more likely to develop ovarian cancer.
The risk is much lower for men. Only 2,240 cases of male breast cancers are diagnosed each year. However, men with the mutation are at a higher risk for other types of cancers including prostate, stomach, pancreatic, and melanoma.
The rule of thumb is that men should consider testing if they have a strong family history of breast or ovarian cancer. Josh was glad he did.
"I do hope to have children someday, and that's very powerful information to have," Josh said.
There's currently no standardized guidelines recommended for men, but men from families with a strong history of breast and ovarian cancer should consider getting tested.
To learn more about Josh's foundation, log onto www.metastaticfoundation.org.
BREAST CANCER GENES: A GUY PROBLEM?
BACKGROUND: Approximately five to ten percent of breast cancers are thought to be hereditary. Most inherited breast cancer cases are associated with two abnormal genes: BRCA1 and BRCA2. Everyone carries them. Their function is to repair cell damage and keep breast cells growing normally. However, when these genes are mutated, they don't function normally and breast cancer risk increases. BRCA1 and BRCA2 abnormal genes account for up to ten percent of all breast cancers, or one out of every ten cases. (Source: http://www.breastcancer.org)
RISKS: Having an abnormal BRCA1 or BRCA2 gene doesn't mean you will be diagnosed with breast cancer. Researchers are discovering that other mutations in parts of chromosomes-called SNPs (single nucleotide polymorphisms)-may be linked to higher breast cancer risk in women with an abnormal BRCA1 gene as well as women who didn't inherit an abnormal breast cancer gene. You are substantially more likely to have an abnormal breast cancer gene if:
* You have blood relatives on either your father's or mother's side of the family who had breast cancer diagnosed before age 50.
* A man in your family has had brea
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